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RGS18 Antibody, FITC conjugated

Datasheet
Code CSB-PA019649LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RGS18 Polyclonal antibody
Uniprot No.
Q9NS28
Target Names
RGS18
Alternative Names
Regulator of G protein signalling 13 antibody; Regulator of G Protein Signalling 18 antibody; Regulator of G-protein signaling 18 antibody; RGS 18 antibody; RGS13 antibody; RGS18 antibody; RGS18_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Regulator of G-protein signaling 18 protein (28-84AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Gene References into Functions
  1. These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq. PMID: 22234696
  2. Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1. PMID: 22210881
  3. molecular cloning and characterization of RGS18 as a regulator of G protein signalling in human platelets PMID: 11955952
  4. gene mapped to chromosome 1. PMID: 16484797
Subcellular Location
Cytoplasm.
Tissue Specificity
Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.
Database Links

HGNC: 14261

OMIM: 607192

KEGG: hsa:64407

STRING: 9606.ENSP00000356430

UniGene: Hs.440890

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